Leelamine
Leelamine is a diterpene amine that has been found in gum resin and has diverse biological activities.{14105,67415,67414} It inhibits pyruvate dehydrogenase kinase (PDHK; IC50 = 9.5 µM).{14105} Leelamine is active against the plant pathogenic fungus B. cinerea (EC50 = 70 µM).{67415} It induces apoptosis in UACC-903 and 1205Lu melanoma cell lines when used at a concentration of 3 µM.{67414} Leelamine (100 and 300 µmol/kg per day) reduces blood glucose levels in an ob/ob mouse model of type II diabetes.{14105}
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