Hesperetin

Hesperetin is a flavonoid that has been found in citrus fruits and has diverse biological activities.{10842,12523,53902,53903,53904} It reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells when used at a concentrations ranging from 10 to 200 µM.{10842} Hesperetin inhibits IgG-induced ?-hexosaminidase release from RBL-2H3 cells (IC50 = 0.099 mg/ml).{12523} It inhibits LPS-induced nitric oxide (NO) production and reduces levels of inducible nitric oxide synthase (iNOS), IL-6, and IL-1? in BV-2 microglial cells.{53902} Hesperetin (5 mg/kg) inhibits passive cutaneous anaphylaxis in mice.{12523} It reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis.{53903} Hesperetin reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation.{53904}