N-Arachidonoyl Taurine

N-Arachidonoyl taurine is an arachidonoyl amino acid.{16245} It is oxygenated by 12(S)- and 15(S)-lipoxygenase and is converted to 12-HETE-taurine (12-HETE-T) in murine resident peritoneal macrophages.{46067} N-Arachidonoyl taurine is an activator of the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4 (EC50s = 28 and 21 µM, respectively).{16245} It increases calcium flux in HIT-T15 pancreatic ?-cells and INS-1 rat islet cells when used at a concentration of 10 µM and increases insulin secretion from 832/13 INS-1 pancreatic ?-cells.{46068} The levels of N-arachidonoyl taurine are changed in mouse brain following administration of ?9-tetrahydrocannabinol (?9-THC).{46069}