Fenofibrate

Fenofibrate is an agonist of peroxisome proliferator-activated receptor ? (PPAR?) with EC50 values of 18 and 30 ?M for mouse and human receptors, respectively, in a transactivation assay.{10670} It is selective for PPAR? over PPAR? (EC50s = 300 and 200 ?M for mouse and human receptors, respectively) and lacks activity at mouse and human PPAR? at a concentration of 100 ?M. In vivo, fenofibrate (50-100 mg/kg) reduces plasma levels of triglycerides, C-reactive protein, and malondialdehyde (MDA) in mice with fructose-induced hypertriglycemia in a dose-dependent manner.{43262} It decreases glomerular and tubular atrophy and necrosis induced by cisplatin (Item No. 13119) in rat kidney when administered at a dose of 100 mg/kg.{43263} Fenofibrate also reduces the number of pulmonary lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in lung in Tsumura Suzuki obese diabetic (TSOD) mice.{43264}