LPA1 Polyclonal Antibody

LPA1 (also known as EDG-2) is one of four known LPA receptors (LPA1-4).{13001} LPA1-3 are part a family of G protein-coupled receptors that share identity to the sphingosine-1-phosphate receptors (S1P1-5).{11049} LPA1 couples with three types of G proteins, Gi/o, Gq, and G12/13 to induce a range of cellular responses including activation of phospholipase C, multiple kinases, the serum response element and cell proliferation.{11808,12477} LPA1 mRNA is detected a wide range of tissues and cells including brain, heart, small intestine, spleen, testis, kidney, HeLa cells, and A549 cells.{11810,12912} Mouse and human LPA1 have 364 amino acids with an estimated molecular weight of 41 kDa.{12477} Cayman’s LPA1 Polyclonal Antibody detects the protein from several species from 43-50 kDa, suggesting heterogeneous LPA1 post-translational modifications in distinct cells.