Docosahexaenoic Acid-d5

Docosahexaenoic acid-d5 (DHA-d5) is intended for use as an internal standard for the quantification of DHA (Item No. 90310) by GC- or LC-MS. DHA is a long-chain ?-3 polyunsaturated fatty acid (PUFA) found in fish and algal oils.{65047} It comprises approximately 40% of total brain PUFAs and is abundant in grey matter and retinal membranes.{65048} DHA typically represents 0.52-7.5% of human total plasma fatty acids. It is produced from ?-linolenic acid (ALA; Item Nos. 90210 | 21910) via a series of desaturase- and elongase-catalyzed reactions, resulting in a docosapentaenoic acid (DPA; Item No. 90165) intermediate, which is elongated, desaturated, and ?-oxidized to produce DHA.{65049} DHA can be liberated from cellular membranes by phospholipase A2 (PLA2) and converted to numerous oxylipins, including specialized pro-resolving mediators (SPMs), which are produced by lipoxygenases and include D-series protectins and resolvins, as well as maresins, that regulate host defense and the resolution of inflammation.{65050} DHA has roles in several physiological and pathological processes, including neural development, cardiovascular diseases, obesity, and inflammation.{65049,65051}