5(S),6(R)-7-trihydroxymethyl Heptanoate

Lipoxins are trihydroxytetraene metabolites derived from arachidonic acid through an interaction between lipoxygenases with C-5 and C-15 specificities. Lipoxin A4 (LXA4) inhibits the chemotactic responsiveness of polymorphonuclear (PMN) neutrophils to leukotriene B4 and to the peptide formyl-methionyl-leucyl-phenylalanine (fMLP).{14813} 5(S),6(R)-7-trihydroxymethyl Heptanoate is a C-7 truncated analog of lipoxin A4 (LXA4) that is equiactive as LXA4 in the inhibition of leukotriene B4 (LTB4)-induced polymorphonuclear neutrophils (PMN) chemotaxis with an IC50 value of 5nM.{14813}