11B-Hydroxysteroid Dehydrogenase (Type 2) Polyclonal Antibody

11?-Hydroxysteroid Dehydrogenase (Type 2) (11?-HSD2) catalyzes the conversion of cortisol (hydrocortisone; Item No. 20739) to the inactive glucocorticoid cortisone (Item No. 30763), thereby protecting the mineralcorticoid receptor from glucocorticoid excess.{12000} It is primarily expressed in the kidneys, but has also been detected in the colon, salivary glands, and fetal tissues, including the placenta, and is localized to the endoplasmic reticulum.{12000,58670} Knockout of HSD11B2, the gene encoding 11?-HSD2, reduces fetal and placental growth as well as capillary development in mice.{58671} Loss-of-function mutations in HSD11B2 result in apparent mineralcorticoid excess (AME), an inborn error of metabolism characterized by hypertension, hypokalemia, and reduced plasma renin activity.{12000} Cayman's 11?-Hydroxysteroid Dehydrogenase (Type 2) Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes 11?-HSD2 at 44 kDa from mouse samples.