Sulindac
Sulindac is a non-steroidal anti-inflammatory drug (NSAID), a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of the COX inhibitor sulindac sulfide (Item No. 10004387).{39154,62991} It is selective for COX-2 over COX-1 (IC50 = >1,000 µM). {62991} It inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats when administered at a dose of 100 mg/kg.{59801} Sulindac (60 mg/kg) reduces tumor growth in a BxPC-3 pancreatic cancer mouse xenograft model.{59802} Formulations containing sulindac have been used in the treatment of pain and inflammation associated with arthritis.
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