11B-Hydroxysteroid Dehydrogenase (Type 1) Polyclonal Antibody

11?-Hydroxysteroid dehydrogenase (Type 1) (11?-HSD1) catalyzes the conversion of inactive cortisone to active cortisol in adipose tissue. mRNA and protein for this enzyme have been detected in a wide range of tissues including liver, kidney, testis, lung, heart, and colon.{12000} The enzyme’s expression is developmentally regulated, suggesting its importance in regulation of glucocorticoid action during embryonic development.{11999} Over-expression of 11?-HSD1 results in visceral obesity and metabolic syndrome including insulin-resistant diabetes, hyperlipidemia, and hyperphagia.{9545} Cayman’s 11?-HSD1 Polyclonal Antibody detects a 32 kDa protein in human, mouse, and rat liver samples by western blot analysis. The antibody can be used on paraffin-embedded tissue sections to detect 11?-HSD1 expression.