SC-236
The physiologic roles and importance of constitutive COX-1 and inducible COX-2 have been reviewed.{11295,10878} SC-236 is a potent, selective, orally active inhibitor of COX-2 with an IC50 of 10 nM and approximately 18,000-fold COX-2 selectivity.{12282} SC-236 has a long plasma half-life and can be dosed once daily (20 mg/kg) in rodents to achieve lasting inhibition of COX-2.{11450}
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