Apoptosis Activator 2
Apoptosis activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation.{11535} This compound has been shown to induce apoptosis in leukemia cells (IC50 = 4-9 ?M) with weak or no effect on normal cell lines or those lacking Apaf-1, caspase-9, or caspase-3 activity (IC50s > 40 ?M).{11535}
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