TP Receptor (mouse) Blocking Peptide

To be used in conjunction with Cayman’s TP receptor (mouse) Polyclonal Antibody (Item No. 101882) to block protein-antibody complex formation during analysis for the TP receptor Thromboxane A2 (TXA2) is a potent vasoconstrictor and activator of platelet aggregation. The short half-life of TXA2 ensures local action whether generated by vascular endothelial cells or by platelets and confers physiologically beneficial or deleterious effects under inflammatory situations.{146,11131} TXA2 elicits its effects via a 7-transmembrane domain G-protein coupled receptor, the TP receptor.{6062} This receptor can also bind prostaglandin H2 and isoprostanes and was first cloned from human placenta and the platelet-like MEG-01 cell line.{11146,7729} The TP receptor is highly expressed in platelets and is relatively less abundant in tissues such as lung, kidney, brain, spleen, thymus, monocytes, uterus, and placenta.{3167,11368,2061,4311} The apparent molecular weight for TP receptors has been reported from 37 to 70 kDa, depending on different degrees of glycosylation,{8380,4311,7235} however Cayman’s antibody consistently detects the TP receptor at 55 and 64 kDa in platelet, kidney and COS-7 cell samples.