Monoclonal Antibody to PD-L1 (Clone: ABM4E54)
PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belonging to the B7 superfamily that inhibits immune responses through its receptor, PD-1. PD-L1 plays a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells, and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274/PD-L1 have been reported during bacterial infection, inflammation, and in numerous autoimmune diseases.
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Monoclonal Antibody to PD-L1 (Clone: ABM4E54)
10-7562
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Monoclonal Antibody to PD-L1 (Clone: ABM4E54)
10-7562
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