Legenda image
Western blot analysis of MBD3 (and MBD2). Anti-MBD3 (and MBD2) antibody (Clone: ABM14A8) was used at 2 µg/ml on A431, K562, A375 and HEK293 lysates.
Product description

MBD2 is a subunit of the NuRD complex that is postulated to mediate gene repression via recruitment of the complex to methylated DNA. This protein binds around 1 kb downstream of the transcription start site of a subset of  400 CpG island promoters that are characterized by the presence of active histone marks, RNA polymerase II (Pol2) and low to medium gene expression levels and H3K36me3 deposition. Methylated MBD2 is involved in silencing methylated tumor suppressor genes as well as activation of pro-metastatic genes. MBD2 also plays a key role in regulating expression of a range of genes that are associated with optimal DC (Dendritic cells) activation and function.

Specifications
Applications
FC, IHC, WB
Host
Mouse
Clonality
Monoclonal
Clone
ABM14A8
Isotype
Mouse IgG1 Kappa
Supplier
Abeomics
Shipping & storage
Shipping condition
Blue Ice
Storage temperature
-20°C

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Productname

Monoclonal Antibody to MBD2/MBD3 (Clone: ABM14A8)

10-7006

By filling out this form, you are placing an order by e-mail. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.


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Productname

Monoclonal Antibody to MBD2/MBD3 (Clone: ABM14A8)

10-7006

By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.


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