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Monoclonal antibody to TRAIL/DR4 (Clone: ABM1B11 )
10-1002
100 ug
€399
Legenda image
Intracellular FLOW analysis of Jurkat cells using 0.5 µgof DR4 antibody (Clone: ABM1B11). Isotype contol mouse IgG1 (ABEOMICS) was used. Goat Anti-mouse PE was used as secondary antibody.
Product description
Death receptor 4 (DR4) or TRAIL-R1, a member of the tumor necrosis factor receptor superfamily, is a cell surface receptor that triggers the apoptotic machinery upon binding to its ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. DR4 expression is enhanced by DNA damage whether induced by ionizing radiation or by chemotherapeutic agents. On binding DR4, TRAIL induces cell death via caspase-dependent apoptosis. DR4 mediates oligomeric Abeta induction of extrinsic apoptotic pathways in human microvascular cerebral endothelial cells with activation of both caspase-8 and caspase-9. It is considered a promising molecular target for cancer therapy.
Specifications
Applications
FC, WB
Host
Mouse
Clonality
Monoclonal
Clone
ABM1B11
Isotype
Mouse IgG1 Kappa
Supplier
Abeomics
Shipping & storage
Shipping condition
Blue Ice
Storage temperature
-20°C
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Monoclonal antibody to TRAIL/DR4 (Clone: ABM1B11 )
10-1002
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Monoclonal antibody to TRAIL/DR4 (Clone: ABM1B11 )
10-1002
By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
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