Catenin beta protein-GST fusion
?-catenins are cytoplasmic proteins that are ubiquitously expressed. These proteins associate with E-cadherin at cellular junctions (1). ?-catenin interacts with TCF and LEF transcription factors and is an essential member of the Wingless-Wnt signal transduction pathway. The adenomatous polyposis coli (APC) tumor-suppressor protein, together with Axin and GSK3?, form a Wnt-regulated signaling complex that mediates phosphorylation-dependent degradation of ?-catenin by the proteasome. APC and Siah-1 mediate a novel ?-catenin degradation pathway linking p53 activation to cell cycle control. Activating mutations in the human ?-catenin gene have been found in human colon cancer and melanomas (2). Catenin ? Protein is ideal for investigators involved in Signaling Proteins, Transcription Proteins, Cancer, Cardiovascular Disease, Invasion/Metastasis, Neurobiology, PKA/PKC Pathway, and WNT Signaling research.
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Catenin beta protein-GST fusion
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Catenin beta protein-GST fusion
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