14-3-3 sigma protein
14-3-3? or stratifin is a protein that is strongly induced by gamma irradiation and other DNA-damaging agents (1). The induction of 14-3-3? is mediated by a p53 responsive element. Exogenous introduction of 14-3-3? into cycling cells results in a G2 cell cycle arrest (2). Knockout of 14-3-3? in cells showed that the cells are unable to maintain cell cycle arrest after DNA damage. The 14-3-3? -/- cells die as they enter mitosis. This process is associated with a failure of the 14-3-3?-deficient cells to sequester the proteins that initiate mitosis and prevent them from entering the nucleus. Thus, 14-3-3? plays an important role in maintaining the G2 checkpoint in cells and preventing mitotic death. 14-3-3? Protein is ideal for investigators involved in Cell Stress& Chaperone Proteins, AKT/PKB Pathway, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, and WNT Signaling research.
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